Macrolane VRF 20 – 10ml

Macrolane® VRF 20 is a stabilized hyaluronic acid (HA) gel implant designed for large-volume soft tissue augmentation and body contouring. It belongs to the NASHA (Non-Animal Stabilized Hyaluronic Acid) technology family developed by Q-Med / Galderma (Sweden). It was used in aesthetic medicine for non-surgical body shaping, particularly for larger anatomical areas requiring volume restoration. ⚠️ Important note: Macrolane has been withdrawn from many markets and is no longer widely available due to safety and imaging concerns, especially in breast applications. Macrolane VRF 20 is a biodegradable, cross-linked hyaluronic acid gel formulated for subcutaneous volumization.

Packaging

• 1 × 10 mL pre-filled syringe (standard format)
• Sterile, single-use medical device
• Gel consistency: thick, cohesive HA implant

Composition

Typical formulation includes:

• Cross-linked hyaluronic acid (approx. 20 mg/mL)
• Phosphate-buffered saline solution
• Stabilized NASHA gel structure (non-animal origin)

Limitations / Regulatory Status

• Withdrawn or restricted in many regions
• Not recommended for breast augmentation due to imaging interference concerns (e.g., mammography issues)
• Requires large injection volumes for body contouring
• Higher cost for large-area treatments

Safety Information

Must only be handled by trained medical professionals.

Possible side effects:

• Swelling
• Bruising
• Lumpiness
• Pain at injection site
• Asymmetry

Rare but serious risks:

• Infection
• Vascular compromise
• Nodules or granuloma formation
• Imaging complications in breast tissue

Key characteristics

• Designed for body contour enhancement (not facial use)
• Medium-density formulation (VRF 20 = less dense than VRF 30)
• Provides temporary volume increase by space filling and water binding
• Injected into deep subcutaneous layers using cannulas

Mechanism of Action

Macrolane VRF 20 works by:

• Physically occupying space in subcutaneous tissue
• Binding water molecules to increase volume effect
• Providing temporary structural augmentation
• Integrating into soft tissue for contour enhancement

It is less dense than VRF 30, allowing:

• Smoother spread in more superficial subcutaneous layers
• More subtle contour correction compared to stronger variants

Product Features

• NASHA stabilized hyaluronic acid technology
• Medium-density volumizing gel (VRF 20)
• Designed for non-surgical body sculpting
• Injectable with cannula into deep subcutaneous tissue
• Temporary implant-like effect (non-permanent)
• Gradual biodegradation over time

Expected Results

Typical outcomes include:

• Immediate visible volume increase
• Improved contour symmetry
• Smoother body surface irregularities
• Temporary augmentation effect

Duration of effect generally reported around 9–18 months, depending on site and metabolism.

1. Non-surgical Volume Restoration

Alternative to surgical implants or fat grafting (historically).

2. Biodegradable Material

Gradually broken down by the body.

3. Adjustable Correction

Can be used in staged treatments.

4. Minimally invasive procedure

Performed via injection rather than surgery.

Common Treatment Areas (Historical Use)

When it was active on the market, Macrolane VRF 20 was used for:

• Body contour irregularities
• Post-liposuction depressions
• Soft tissue asymmetries
• Buttocks shaping (limited use)
• Calves and lower limb contouring
• Chest and breast augmentation (later discouraged/restricted)