Hyaluronidase 1,500 IU

Hyaluronidase 1,500 IU is a prescription enzyme preparation used to temporarily break down hyaluronic acid (HA) in connective tissues. In aesthetic medicine, it is commonly used to dissolve hyaluronic acid dermal fillers, correct overfilled or uneven results, and assist in the emergency management of vascular occlusion caused by HA filler injections. It may also be used to enhance the dispersion and absorption of injected medications and fluids. Hyaluronidase should be administered only by qualified healthcare professionals trained in its appropriate use. Hyaluronidase is an enzyme that hydrolyzes hyaluronic acid, reducing its viscosity and allowing it to be naturally absorbed by the body. It is an essential product in aesthetic practices where hyaluronic acid fillers are used.

Packaging

• 1 sterile vial containing 1,500 IU (International Units) of hyaluronidase
• Lyophilized (freeze-dried) powder for reconstitution
• Single-use vial
• Requires reconstitution with sterile saline before administration

Composition

Each vial contains:

• Hyaluronidase: 1,500 IU

Inactive ingredients vary by manufacturer and may include stabilizers such as:

• Human albumin or gelatin (depending on formulation)
• Sodium chloride or phosphate buffer

Safety Information

Hyaluronidase should only be administered by qualified healthcare professionals.

Possible side effects include:

• Injection-site pain
• Redness
• Swelling
• Bruising
• Temporary tenderness
• Mild itching

Rare but serious risks include:

• Allergic or hypersensitivity reactions
• Anaphylaxis (rare)
• Excessive dissolution of surrounding hyaluronic acid
• Local tissue irritation

Contraindications:

• Known hypersensitivity to hyaluronidase or any formulation component
• Injection into infected or inflamed tissue
• Use with non-hyaluronic acid fillers (such as calcium hydroxylapatite or polymethylmethacrylate) will not dissolve these materials
• Caution in patients with a history of severe allergic reactions

Storage

• Store according to the manufacturer’s instructions, generally at 2°C–25°C, protected from light.
• Once reconstituted, the solution should be used promptly or within the time specified by the manufacturer.

Key Characteristics

• Enzymatic preparation
• Sterile lyophilized powder
• Rapid onset of action
• Specifically effective against hyaluronic acid-based fillers
• Intended for professional medical use only

Mechanism of Action

Hyaluronidase works by:

• Breaking down hyaluronic acid into smaller molecules
• Reducing the viscosity of connective tissue
• Accelerating the natural absorption of hyaluronic acid
• Dissolving hyaluronic acid dermal fillers
• Improving tissue permeability and diffusion of injected substances

Its effects begin within minutes after administration, with continued enzymatic activity over the following hours.

Product Features

• 1,500 IU of hyaluronidase per vial
• Rapid enzymatic degradation of hyaluronic acid
• Effective for dissolving most HA-based dermal fillers
• Lyophilized powder for reconstitution
• Fast onset of action
• Suitable for aesthetic and selected medical applications
• Single-use sterile vial

Expected Results

Following administration, patients may experience:

• Gradual reduction or complete dissolution of hyaluronic acid filler
• Correction of overfilled or uneven treatment areas
• Improved blood flow in cases of vascular compromise when treated promptly
• Restoration of normal tissue appearance

The degree of filler dissolution depends on:

• Type and amount of filler
• Degree of cross-linking
• Injection technique
• Dose of hyaluronidase administered
• Time elapsed since filler placement

Advantages

• Rapid action
• Highly effective for dissolving hyaluronic acid fillers
• Valuable emergency treatment for vascular occlusion
• Helps correct aesthetic complications
• Improves flexibility in filler treatments
• Widely used in aesthetic medicine

Common Clinical Applications

A qualified healthcare professional may use Hyaluronidase for:

• Correction of excessive or misplaced HA filler
• Treatment of asymmetrical filler results
• Management of vascular compromise following HA filler injections
• Removal of unwanted lip, cheek, chin, jawline, or tear trough fillers
• Enhancement of absorption of subcutaneous fluids or medications in selected medical settings