Macrolane VRF 30 – 20ml

Macrolane® VRF 30 (20ml) is a high-density stabilized hyaluronic acid (NASHA) injectable gel implant designed for large-volume body contouring and deep tissue augmentation. It was developed by Q-Med (Galderma, Sweden) as part of the Macrolane VRF system used for non-surgical body sculpting and volumetric restoration. It is intended only for administration by trained medical professionals, and its use is now restricted or discontinued in many markets due to safety and diagnostic concerns.

Packaging

• 1 × 20.0 mL pre-filled sterile syringe
• Single-use medical device
• Cross-linked NASHA hyaluronic acid gel

This is a large-volume presentation designed for extensive body contouring procedures.

Composition

• Cross-linked hyaluronic acid (NASHA technology)
• Approx. ~20 mg/mL HA concentration (typical Macrolane formulation range)
• Phosphate-buffered saline solution
• Biocompatible, non-animal origin stabilized gel

Limitations / Regulatory Status

• Largely discontinued or restricted globally
• Not commonly used in modern aesthetic practice
• Breast applications discouraged due to imaging complications
• Requires high injection volumes for visible effect

Safety Information

Must only be used by qualified healthcare professionals.

Possible side effects:

• Swelling
• Bruising
• Pain or tenderness
• Irregular contour formation
• Nodules or firmness

Rare but serious risks:

• Infection
• Vascular compromise
• Inflammatory reactions
• Interference with diagnostic imaging (especially breast tissue)

Mechanism of Action

Macrolane VRF 30 works by:

• Occupying deep subcutaneous tissue spaces
• Creating volume through space-filling and water binding
• Providing temporary implant-like augmentation without surgery
• Integrating into soft tissue for contour shaping and support

Compared to VRF 20, VRF 30 provides:

• Higher structural firmness
• Stronger lifting and projection
• Better support for defined contouring

Product Features

• NASHA stabilized hyaluronic acid gel
• High-density formulation for deep volumizing
• Injectable via cannula into subcutaneous layers
• Temporary, biodegradable implant-like effect
• Large-volume (20 mL) professional presentation
• Strong contouring capability

Expected Results

• Immediate and visible volume increase
• Improved body contour symmetry
• Smoother correction of depressions
• Natural soft-tissue augmentation effect

Duration typically:

• ~12–18 months, depending on area and metabolism

Advantages

• Non-surgical body sculpting option
• No permanent implants required
• Biodegradable hyaluronic acid material
• Adjustable and repeatable treatment approach
• Predictable volumizing effect in deep tissue

Common Treatment Areas (Historical Use)

Macrolane VRF 30 (20 mL) was used for:

• Buttock augmentation and reshaping
• Calf volume enhancement
• Body contour irregularities
• Post-liposuction depressions
• Soft tissue asymmetry correction
• Breast augmentation (later discontinued/restricted)

⚠️ Breast use was later restricted due to interference with mammography and cancer imaging interpretation.