Macrolane VRF 20 – 20ml

Macrolane® VRF 20 (20ml) is a stabilized hyaluronic acid (NASHA) injectable gel designed for large-volume soft tissue augmentation and body contour correction. It was developed by Q-Med (now part of Galderma, Sweden) and used in aesthetic medicine as a non-surgical body filler for volume restoration and contouring.

Packaging

• 1 × 20.0 mL pre-filled sterile syringe
• Single-use medical device
• Cross-linked NASHA hyaluronic acid gel

This larger 20 mL format is intended for extensive body areas where higher total volume is required.

Composition

Typical formulation includes:

• Cross-linked hyaluronic acid (approx. 20 mg/mL)
• Physiological buffer solution (phosphate-buffered saline)
• Non-animal stabilized hyaluronic acid (NASHA technology)

Limitations / Status

• Largely discontinued or restricted in many markets
• Not widely used today in aesthetic practice
• Breast applications discouraged due to diagnostic imaging interference risks
• Requires large injection volumes for effect

Safety Information

Must only be used by qualified medical professionals.

Possible side effects:

• Swelling
• Bruising
• Pain at injection site
• Irregular contour formation
• Nodules or firmness

Rare risks:

• Infection
• Vascular complications
• Inflammatory reactions
• Imaging interference in breast tissue

Mechanism of Action

Macrolane VRF 20 works by:

• Occupying large subcutaneous tissue spaces
• Binding water to create volume expansion
• Providing temporary implant-like augmentation without surgery
• Integrating into soft tissue for contour correction

Compared to VRF 30:

• VRF 20 spreads more easily
• Better suited for broader, less dense contour areas

Product Features

• NASHA stabilized hyaluronic acid gel
• Medium-density formulation (VRF 20)
• Designed for large-volume body contouring
• Injectable via cannula into deep subcutaneous tissue
• Temporary volumizing effect (biodegradable HA)
• Provides smooth tissue expansion

Expected Results

• Immediate visible volume increase
• Improved body contour symmetry
• Smoother surface defects
• Natural soft-tissue augmentation effect

Duration typically:

• ~9–18 months, depending on area and metabolism

Advantages

• Non-surgical body shaping option
• Biodegradable hyaluronic acid
• Adjustable and repeatable treatment
• No permanent implant required
• Natural tissue integration

Common Treatment Areas (Historical Use)

Macrolane VRF 20 (20 mL) was used for:

• Body contouring and reshaping
• Buttocks augmentation
• Calf volume enhancement
• Correction of post-liposuction irregularities
• Soft tissue depressions and asymmetries
• Limited breast augmentation use (later restricted)

⚠️ However, regulatory authorities later advised against breast use due to imaging complications in cancer screening.